Cold sore virus harder to shake than previously thought

A lot of people are of the belief that once they have undertaken their treatment for cold sores and the blemishes are beginning to become less conspicuous, they are able to relax and worry less about passing on the virus to other people, whether by sharing cups and cutlery, or through kissing.

Nerves

However, a new piece of research by Australian National University (ANU) has revealed that the herpes simplex (HSV-1) virus may actually be contagious up to 10 days following infection, meaning that even once you have finished your course of cold sore treatment you may have to continue taking precautions.

Details of the Australian study, which were published in the journal PLOS Pathogens, show how the "damaging genes" of the virus spread throughout the nervous system and are able to begin further infection even after blisters have faded.

"The traditional view of viral latency, and particularly in the case of HSV-1, is that the virus is either active or not active and there's not much in-between," commented Professor David Tscharke from the Department of Immunology and Infectious Disease at the ANU's John Curtin School of Medical Research.

"But now we know that the HSV-1 virus is still spreading in the nervous system at a time that most people thought the acute phase was over. So you might think that once the physical cold sore has gone, you are well and that the virus is entirely beaten but your immune system is still fighting it for you."

The revelation, which was achieved as a result of tests on mice, means that we now know that the herpes virus lasts for twice as long as previously thought. "You can't see it [on the body] but the virus is still spreading underground," said the scientists.

It also helps explain why so many people are prone to recurrent infections; if the immune system becomes low after symptoms have gone and cold sore treatment has been taken, sufferers may find themselves prone to a second outbreak.

Making changes to your lifestyle choices can be a good way to tackle the virus and therefore reduce the need for aggressive treatment for cold sores.

DNA treatment breakthrough but cold sore creams still the best

Herstat may be clinically proven to be one of the best cold sore creams on the market but even we look forward to the day when the herpes virus that is responsible for so many unsightly and uncomfortable blemishes is eradicated altogether.

And this is not only for cosmetic reasons; the cold sore virus is responsible for many serious illnesses, from shingles and blindness to brain injury, glandular fever, birth defects and even some types of cancers – only now is it become clear how many serious health conditions the cold sore virus is implicated in.

DNA helix

This is why we are pleased to hear news from scientists at the University Medical Centre in Utrecht, the Netherlands, that gene therapy has the potential to expunge the herpes virus from the individual human body.

By using CRISPR, a "gene-editing technique", scientists are able cut DNA at particular points in a sequence. This may be able to permanently disable dormant viruses, leaving them unable to repair. However, getting the technique right is easier said than done; cutting DNA sequences can result in errors or unhelpful mutations in genetic code.

So far there has been some success. Scientists have found that by cutting DNA from one particular type of herpes virus they were able to reduce viral activity by half; cuts in two locations resulted in 95 per cent of dormant viruses being eliminated.

"We could efficiently remove the latent genome from infected cells, essentially curing cells from their invader," said one of the scientists.

It is also worth noting that the scientists have so far been less successful in gene editing the virus responsible for cold sores, meaning that sufferers may still be searching for the best cold sore cream on the market for some years yet!

"Magic bullet" offers hope in fight against cold sores

Don't believe in magic? Well, soon you might with news that scientists are developing a cold sore remedy that could be part of a "magic bullet" weapon against a whole host of viral infections including Zika, Ebola, dengue and influenza.

Interestingly, the proposed virus and cold sore remedy is being developed with the assistance of IBM's Watson supercomputer, which has been instrumental in developing a chemical that has all the properties required to block even the most virulent of viruses.

Washing hands

According to IBM and Singapore's Institute of Bioengineering and Nanotechnology (IBN), which has been working in partnership on the project, the remedy works by attracting viruses and then electrostatically bonding to proteins on their surfaces, neutralising their pH levels and making it impossible for them to replicate.

In addition, the magic bullet, which is part of a field of medical science called macromolecular biology, then releases sugars which bind to healthy immune cells thereby preventing viruses from being able to infect them.

Given the recent Zika and Ebola crises, news of the breakthrough has come at a welcome time, with the need to achieve anti-viral breakthroughs more important than ever.

"We have created an anti-viral macromolecule that can tackle wily viruses by blocking the virus from infecting the cells, regardless of mutations," explained Dr. Yi Yan Yang, Group Leader at the Institute of Bioengineering and Nanotechnology. "It is not toxic to healthy cells and is safe for use. This promising research advance represents years of hard work and collaboration with a global community of researchers."

It is thought that the chemical could have many applications, although the researchers anticipate that it will be used in soap and other similar health and hygiene products.

"My gut feeling is, something like a wipe, something like a hand cleaner is going to be relatively straightforward to move to market. It you market it as a true antiviral, I would imagine it would take 3, 4, 5 years maybe maximum," said Dr, Yi Yan Yang.

NHS should take note of cold sore treatment

One of Britain's most inspirational business leaders, Sir Michael Lockett, who was a key figure in both the London 2012 Olympics opening ceremony and the Queen's Diamond Jubilee river pageant, has revealed that he has a revolutionary cold sore treatment to thank for the curing of his neck and head cancers.

London Tower Bridge

Although the cold sore treatment was only at its trial stages when Lockett was first placed on it in 2009, his doctors have now given him the news he has been longing to hear: his cancer appears to be cured.

The cold sore-based cancer treatment is truly a medical marvel. It takes the form of a drug, Imlygic, which is comprised of a genetically modified version of the herpes virus to stimulate the immune system into targeting tumours that were previously thought to be inoperable. Lockett's cancer was resistant to both radiotherapy and chemotherapy, a situation which led him to contact scientists at the Institute of Cancer Research in the hope of being included in the early cold sore treatment trial.

It is a sad addendum then that the National Institute for Health and Care Excellence (NICE) has so far failed to give approval to the drug for the treatment of some aggressive cancers – a situation many campaigners have branded "unacceptable".

The treatment is incredibly sophisticated. The modified herpes virus avoids healthy cells and instead targets cancer cells where it then multiplies, causing them to rupture and provoking a natural immune response.

"The herpes virus appears to be a very powerful killer of cancer," commented Professor Kevin Harrington from the Royal Marsden Hospital

Forensic virology study could lead to new cold sore treatment

MicrobiologistYes, Herstat may be an effective cold sore treatment, but one of the many paradoxes of science is that we are still struggling to find a cure for the virus at a time when understanding of its pathology and characteristics is proving useful in countless other ways.

A couple of months ago there was talk of using the cold sore virus as a pioneering treatment for cancer and now medical and science journals are talking about using analysis of the HSV-1 virus to help identify a person's origin.

This is because scientists at Pennsylvania State University have been able to identify three varieties of the HSV-1 virus: African, Asian and European/North American.

Although this might sound very theoretical, the scientists believe that the technique could have many practical applications. For example, although DNA can provide useful data about a person's genetic makeup it cannot give other useful information such as details of a person's life story, such as where they grew up.

"Forensic virology could be on the way in the same way in which we use genetic fingerprinting of our human DNA to locate perpetrators at the scene of a crime and to help trace the relatives of unidentified bodies," commented one of the study authors.

Senior author Moriah L. Szpara, assistant professor of biochemistry and molecular biology at Pennsylvania State University, says that because improved genomic analysis will help us better understand the workings of HSV-1, it could also lead to new and improved cold sore treatments in the future. The potential for any such development could be huge; currently around 3.7 billion people in the world (67%) have the HSV-1virus.

To find out more about cold sore treatments and how Herstat can help, please click here.

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